Synthetic lethality of mRNA quality control complexes in cancer

Nature, Published online: 05 February 2025; doi:10.1038/s41586-024-08398-6PELO–HBS1L and SKI complexes in the human mRNA quality control pathway exhibit a synthetic lethal interaction and may represent novel targets for the development of cancer therapies.

Feb 5, 2025 - 20:35
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Synthetic lethality of mRNA quality control complexes in cancer

Nature, Published online: 05 February 2025; doi:10.1038/s41586-024-08398-6PELO–HBS1L and SKI complexes in the human mRNA quality control pathway exhibit a synthetic lethal interaction and may represent novel targets for the development of cancer therapies.