Lineage tracing of stem cells decades after blood and bone-marrow transplantation
Nature, Published online: 05 February 2025; doi:10.1038/d41586-025-00345-3In individuals receiving an allogeneic haematopoietic cell transplant, stem cells in the bone marrow, which give rise to blood and immune cells, are replaced with those from a donor. Genome-sequencing analyses in donor–recipient pairs years after transplantation show an accelerated loss of clonal diversity in the blood stem cells of recipients compared with those of donors.
Nature, Published online: 05 February 2025; doi:10.1038/d41586-025-00345-3In individuals receiving an allogeneic haematopoietic cell transplant, stem cells in the bone marrow, which give rise to blood and immune cells, are replaced with those from a donor. Genome-sequencing analyses in donor–recipient pairs years after transplantation show an accelerated loss of clonal diversity in the blood stem cells of recipients compared with those of donors.
